Analgesic and antiinflammatory activities of the capilliposide derived from Lysimachia capillipes Hemsl., a traditional Chinese medicinal herb

Authors

  • Zhipan Wu College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Haote Han College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Mengting Xu College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Yuhang Shen College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Chengcheng Gao College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Huahua Yuan College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Shouxin Li 1. College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027; 2. Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang-Malaysia Joint Research Center for Traditional Medicine, Zhejiang University, Hangzhou 310027
  • Jingkui Tian 1. College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027; 2. Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang-Malaysia Joint Research Center for Traditional Medicine, Zhejiang University, Hangzhou 310027
  • He Ye Department of Pharmacy, Zhejiang Hospital, Hangzhou 310013

DOI:

https://doi.org/10.2298/ABS200708045W

Keywords:

capilliposide, Lysimachia capillipes Hemsl., antiinflammatory, analgesic

Abstract

Paper description:

  • The Lysimachia capillipes Hemsl capilliposide (LCc) is the main bioactive component of this Chinese medicinal plant.
  • Hot-plate, body torsion and paw swelling tests, together with changes in MDA, PGE2, TNF-α, COX-1 and COX-2 levels in paw tissues determined by ELISA served to estimate the analgesic and anti-inflammatory effects of LCc in female IRC mice.
  • The presented results describe analgesic and anti-inflammatory effects of LCc and lay the foundations for further investigations of its bioactivity.

Abstract: Pain and inflammation are associated with the pathophysiology of different clinical conditions. The Lysimachia capillipes Hemsl. capilliposide (LCc) is the main bioactive component of this Chinese medicinal herb, which is widely used as a remedy for the treatment of colds and arthritis. This study investigated the analgesic and antiinflammatory activities of LCc in an animal model. LCc had no significant influence on the spleen, lung, liver and stomach coefficients in mice. Pharmacological studies showed that LCc at all doses (40, 60 and 90 mg/kg) increased the latency period of paw licking induced by thermal stimulation, and at the dose of 40 mg/kg it significantly suppressed abdominal writhing episodes of mice induced by intraperitoneal (i.p.) injection of acetic acid. LCc also had antiinflammatory effect on inflammation models. Doses of 60 and 90 mg/kg suppressed paw edema induced by subcutaneous (s.c.) injection of carrageenan. Mechanistic studies revealed that the antiinflammatory effect of LCc was associated with inhibition of the production of malondialdehyde (MDA), prostaglandin E2 (PGE2), tumor necrosis factor (TNF-α), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in paw tissue of carrageenan-injected mice. These results show that LCc has analgesic and antiinflammatory effects in mice.

Downloads

Download data is not yet available.

References

Elberry AA, Sharkawi SMZ, Wahba MR. Antinociceptive and anti-inflammatory effects of N-acetylcysteine and verapamil in Wistar rats. Korean J Pain. 2019;32(4):256-63.

Rafieian-Kopaei M, Shakiba A, Sedighi M, Bahmani M. The analgesic and anti-inflammatory activity of Linum usitatissimum in Balb/c mice. J Evid Based Complementary Altern Med. 2017;22(1): 892-6.

Hernández-Ortega M, Ortiz-Moreno A, Hernández-Navarro MD, Chamorro-Cevallos G, Necoechea-Mondragón H. Antioxidant, antinociceptive, and anti-inflammatory effects of carotenoids extracted from Dried Pepper (Capsicum annuum L.). J Biomed Biotechnol. 2012;2012:524019.

Samad MB, D’Costa NM, Kabir A, Hannan JMA. Investigation on central and peripheral analgesic and anti-inflammatory activity of Punarnavasava, an Ayurvedic preparation. European J Med Plants. 2013;3(1):146-62.

Vittalrao AM, Shanbhag T, Kumari M, Bairy KL, Shenoy S. Evaluation of antiinflammatory and analgesic activities of alcoholic extract of Kaempferia galanga in rats. Indian J Physiol Pharmacol. 2011;55(1):13-24.

Medzhitov, Ruslan. Origin and physiological roles of inflammation. Nature. 2008;454(7203):428-35.

Fuccelli R, Fabiani R, Sepporta MV, Rosignoli P. The hydroxytyrosol-dependent increase of TNF-α in LPS-activated human monocytes is mediated by PGE2 and adenylate cyclase activation. Toxicol In Vitro. 2015;29(5):933-7.

Garni B, David AH, Christopher CG. The Molecular Pathophysiology of Concussive Brain Injury. Clin Sport Med. 2011;30(1):33-48.

Artimani T, Karimi J, Mehdizadeh M, Yavangi M, Khanlarzadeh E, Ghorbani M, Asadi S, Kheiripour N. Evaluation of pro-oxidant-antioxidant balance (PAB) and its association with inflammatory cytokines in polycystic ovary syndrome (PCOS). Gynecol Endocrin. 2018;34(2):148-52.

Posadas I, Bucci M, Roviezzo F, Rossi A, Parente L, Sautebin L, Cirino G. Carrageenan‐induced mouse paw oedema is biphasic, age‐weight dependent and displays differential nitric oxide cyclooxygenase‐2 expression. Br J Pharmacol. 2004;142(2):331-8.

Chen JY, Si M, Wang Y, Liu LH, Zhang YF, Zhou AW, Wei W. Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2. Inflammopharmacology. 2019;27(1):157-66.

Siddalingappa C, Radesh T, Kudagi BL, Krishnakanth K, Sujith TR. Evaluation of analgesic and anti-inflammatory activities of Tinospora cordifolia in rodents. Int J Basic Med Sci. 2011;2(6):305-11.

Chang CW, Liao JC, Chiu YJ, Hsieh MT, Peng WH, Lin YC. Analgesic and anti-inflammatory activities of methanol extract of Cissus repens in mice. Evid Based Compl Alt. 2012;2012:135379.

Hajhashemi VI, Ghannadi A, Sedighifar S. Analgesic and anti-inflammatory properties of the hydroalcoholic, polyphenolic and boiled extracts of Stachys lavandulifolia. Res Pharm Ences. 2007;2(2):92-8.

Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 1990;186(186):421-31.

Yin L, Guan ES, Zhang YB, Shu ZH, Wang B, Wu XL, Chen J, Liu JX, Fu XY, Sun WH, Liu MF. Chemical profile and anti-inflammatory activity of total flavonoids from glycyrrhiza uralensis fisch. Iran J Pharm Res. 2018;17(2):726-34.

Asadi-Samani M, Kooti W, Aslani E, Shirzad H. A systematic review of Iran's medicinal plants with anticancer effects. J Evid Based Complementary Altern Med. 2015;21(2):143-53.

Fasihzadeh S, Lorigooini Z, Jivad N. Chemical constituents of Allium stipitatum regel (persian shallot) essential oil. Der Pharmacia Lettre. 2016;8(1):175-80.

Ghasemi S, Lorigooini Z. A review of significant molecular mechanisms of flavonoids in prevention of prostate cancer. J Chem Pharm Sci. 2016;9(4):3388-94.

Rabiei Z, Bigdeli MR, Lorigooini Z. A review of medicinal herbs with antioxidant properties in the treatment of cerebral ischemia and reperfusion. J Babol Univ Med Sci. 2015;17(12):47-56.

Hajian S. Positive effect of antioxidants on immune system. Immunopathologia Persa. 2015;1(1):e02.

Srebro DP, Vučković S, Milovanović A, Vujović KS, Vučetić Č, Prostran M. Preventive treatment with dizocilpine attenuates oedema in a carrageenan model of inflammation: the interaction of glutamatergic and nitrergic signaling. Inflammopharmacology. 2019;27(1):121-8.

Srebro DP, Vučković S, Vujović KS, Prostran M. Anti-hyperalgesic effect of systemic magnesium sulfate in carrageenan-induced inflammatory pain in rats: influence of the nitric oxide pathway. Magnes Res. 2014;27(2):77-85.

Pongpun S, Chariya H, Jantana Y, Suratsawadee P, Kwanjai K, Ngampong K, Somsak R, Naoto O. Induction of apoptosis by Rhinacanthone isolated from Rhinacanthus nasutus roots in human cervical carcinoma cells. Biol Pharm Bull. 2009;32(7):1251-60.

Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci. 2005;78(5):431-441.

Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol. 2005;99(1):72-9.

Setzer W, Setzer M. Plant-derived Triterpenoids as potential antineoplastic agents. Minirev Med Chem. 2003;3(6):540-56.

Martín R, Ibeas E, Carvalho-Tavares J, Hernández M, Ruiz-Gutierrez V, Nieto ML. Natural Triterpenic Diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation. Plos One. 2009;4:e5975.

Tian JK, Xu LZ, Zou ZM, Yang SL. Three novel Triterpenoid Saponins from Lysimachia capillipes and their cytotoxic activities. Chem Pharm Bull. 2006;54(4):567-9.

Fei ZH, Kan W, Yun LC, Bing W, Shi RZ, Sheng LM. Capilliposide isolated from Lysimachia capillipes Hemsl. induces ROS generation, cell cycle arrest, and apoptosis in human nonsmall cell lung cancer cell lines. Evid Based Complementary Alternat Med. 2014;2014:1-11.

Cheng ZZ, Zhou X, Hu BY, Li WY, Chen GY, Zhang Y, Tian JK, Zhang L, Li M, Jiang HL. Tissue distribution of capilliposide B, capilliposide C and their bioactive metabolite in mice using liquid -tandem mass spectrometry. Biomed Chromatogr. 2017;31(6): e3895.

Cheng ZZ. The metabolism and pharmacokinetics of capilliposide B and capilliposide C in Lysimachia capillipes Hemsl extract [dissertation]. [Hubei (HB)]: University of Science and Technology; 2015. 153 p.

Tian JK, Xu LZ, Zou ZM, Yang SL. Two new triterpene saponins from Lysimachia capillipes. J Asian Nat Prod Res. 2006;8(5):439-44.

Liang B, Zhang L, Tian J, Xu L, Yang S. Isolation and characterization of two new saponins from Lysimachia capillipes. Carbohyd Res. 2006;341(14):2444-8.

Ying HM, Qi ZJ, Guo DW, Yu TL, Zhang L, Tian JK. Quantitative determination of capilliposide B and capilliposide C in Lysimachia capillipes by HPLC-ELSD assay. Chin Pharmacol J. 2011;46(9):704-6.

Yan XU, Rong YM, Xiao BL, Ying HM, Zou LB, Tian JK. Experimental studies on anti-tumor effects of Capilliposide. Chin Pharmacol Bull. 2012;28:545-9.

O'Callaghan JP, Holtzman SG. Quantification of the analgesic activity of narcotic antagonists by modified hot plate procedure. J Pharmacol Exp Ther. 1975;192(3):497-505.

Younos C, Rolland A, Fleurentin J, Lanhers MC, Mortier F. Analgesic and behavioural effects of Morinda citrifolia. Planta Med. 1990;56(5):430-4.

Zhang L, Hu JJ, Lin JW, Fang WS, Du GH. Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of Pterocephalus hookeri (C.B Clarke) HÖeck. J Ethnopharmacol. 2009;123(3):510-4.

Naghizadeh B, Mansouri MT, Ghorbanzadeh B. Ellagic acid enhances the antinociceptive action of carbamazepine in the acetic acid writhing test with mice. Pharm Biol. 2015;54(1):157-61.

Akinnawo OO, Anyasor GN, Osilesi O. Aqueous fraction of Alstonia boonei de Wild leaves suppressed inflammatory responses in carrageenan and formaldehyde induced arthritic rats. Biomed Pharmacother. 2017;86:95-101.

Singh H, Ghosh MN. Modified plethysmometer for measuring foot volume of unanesthetized rats. J Pharm Pharmacol. 1968;20(4):316-7.

Wang SH, Luo J, Lv HH, Zhang ZH, Yang JC, Dong DD, Fang YW, Hu LJ, Liu MY, Liao ZC, Li J, Fang ZC, Wei YP, Han W, Shaikh AB, Yin DC, Shang P. Safety of exposure to high static magnetic fields (2 T–12 T): a study on mice. Eur Radiol. 2019;29(11):6029-37.

Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011;335(1):2-13.

Pashmforosh M, Vardanjani HR, Vardanjani HR, Pashmforosh M, Khodayar MJ. Topical anti-inflammatory and analgesic activities of Citrullus colocynthis extract cream in rats. Medicina. 2018;54(4):51-61.

Collier HOJ, Dinneen LC, Johnson CA, Schneider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Brit J Pharmacol. 1968;32(2):295-310.

Deraedt R, Jouquey S, Delevallée Fo, Flahaut M. Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur J Pharmacol. 1980;61(1):17-24.

Bonini SA, Premoli M, Tambaro S, Kumar A, Maccarinelli G, Memo M, Mastinu A. Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. J Ethnopharmacol. 2018;227:300-15.

Zhang X, Cheng X, Wu YL, Feng D, Qian YF, Chen LP, Yang B, Gu MC. In vitro and in situ characterization of the intestinal absorption of capilliposide B and capilliposide C from lysimachia capillipes hemsl. Molecules. 2019;24(7):1227-41.

Piao Y, Liu Y, Xie X. Change trends of organ weight background data in Sprague Dawley rats at different ages. J Toxicol Pathol. 2013;26(1):29-34.

Jagonia RVS, Dela Victoria RG, Bajo LM, Tan RS. Conus striatus venom exhibits non-hepatotoxic and non-nephrotoxic potent analgesic activity in mice. Mol Biol Rep. 2019;46(5):5479-86.

Liu J, Shi JZ, Yu LM, Goyer RA, Waalkes MP. Mercury in traditional medicines: Is cinnabar toxicologically similar to common mercurials? Exp Biol Med. 2008;233(7):810-7.

Bukhari IA, Khan RA, Gilani AH, Ahmed S, Saeed SA. Analgesic, anti-inflammatory and anti-platelet activities of the methanolic extract of Acacia modestaleaves. Inflammopharmacology. 2010;18(4):187-96.

Taber RI, Greenhouse DD, Iewin S. Inhibition of phenylquinone-induced writhing by narcotic antagonists. Nature. 1964;204(4954):189-90.

Burch RM, Dehaas C. A bradykinin antagonist inhibits carageenan edema in rat. Arch Für Exp Pathol Pharmakol. 1990;342(2):189-93.

Odabasoglu F, Halici Z, Aygun H, Halici M. α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations. Br J Nutr. 2011;105(01):31-43.

Qian HY, Yuan HH, Wang J, Du YX, Zhang XL, Sun Y, Li ZG, Zhao WM. A monoclonal antibody ameliorates local inflammation and osteoporosis by targeting TNF-α and RANKL. Int Immunopharmacol. 2014;20(2):370-6.

Annamalai P, Thangam EB. Local and systemic profiles of inflammatory cytokines in carrageenan-induced paw inflammation in rats. Immunol Commun. 2017;46(3):274-83.

Yu HH, Wu XL, Zhang M, Ning B. Prostaglandin E 2 in peripheral blood and tumor mass of patients with gastric cancer. Acta Acad Med Mil Tertiae. 2008;30:444-6.

Mitra RS, Judge TA, Nestle FO, Turka LA, Nickoloff BJ. Psoriatic skin-derived dendritic cell function is inhibited by exogenous IL-10. Differential modulation of B7-1 (CD80) and B7-2 (CD86) expression. J Immunol. 1995;154(6):2668-77.

Díaz-Muñoz MD, Osma-García IC, Cacheiro-Llaguno C, Fresno M, íñiguez MA. Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages. Cell Signal. 2010;22(10):1427-36.

Álvarez-Soria MA, Herrero-Beaumont G, Moreno-Rubio J, Calvo E, Santillana J, Egido J, Largo R. Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis. Osteoarthr Cartilage. 2008;16(12):1484-93.

Liao Z, Milas L. COX-2 and its inhibition as a molecular target in the prevention and treatment of lung cancer. Expert Rev Anticanc. 2004;4(4):543-60.

Zheng SX, Wang Q, He Q, Song XR, Ye DY, Gao F, Jin SW, Lian QQ. Novel biphasic role of LipoxinA4 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts. Mediat Inflamm. 2011;2011: 745340.

Huang GJ, Pan CH, Liu FC, Wu TS, Wu CH. Anti-inflammatory effects of ethanolic extract of Antrodia salmonea in the lipopolysaccharide-stimulated RAW246.7 macrophages and the λ-carrageenan-induced paw edema model. Food Chem Toxicol. 2012;50(5):1485-93.

Li YY, Huang SS, Lee MM, Deng JS, Huang GJ. Anti-inflammatory activities of cardamonin from Alpinia katsumadai through heme oxygenase-1 induction and inhibition of NF-κB and MAPK signaling pathway in the carrageenan-induced paw edema. Int Immunopharmacol. 2015;25(2):332-9.

Aoki T, Narumiya S. Prostaglandins and chronic inflammation. Trends Pharmacol Sci. 2012;33(6):304-11.

Yu HH, Lin Y, Zeng R, Li X, Zhang T, Tasneem S, Chen C, Qiu YX, Li B, Liao J, Wang YH, Cai X, Wang W. Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb. J Ethnopharmacol. 2019;238:111902-11.

Ziegler A, Fogle C, Blikslager A. update on the use of cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs in horses. J Am Vet Med Assoc. 2017;250(11):1271-4.

Downloads

Published

2020-12-25

How to Cite

1.
Wu Z, Han H, Xu M, Shen Y, Gao C, Yuan H, Li S, Tian J, Ye H. Analgesic and antiinflammatory activities of the capilliposide derived from Lysimachia capillipes Hemsl., a traditional Chinese medicinal herb. Arch Biol Sci [Internet]. 2020Dec.25 [cited 2024Apr.16];72(4):515-23. Available from: https://serbiosoc.org.rs/arch/index.php/abs/article/view/6037

Issue

Vol. 72 No. 4 (2020)

Section

Articles

License

Copyright (c) 2020 Archives of Biological Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Authors grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.