TY - JOUR AU - Singh, Ram S. AU - Walia, Amandeep K. PY - 2019/10/23 Y2 - 2024/03/29 TI - Antioxidant and antimicrobial activities of Penicillium sp. lectins JF - Archives of Biological Sciences JA - Arch Biol Sci VL - 71 IS - 3 SE - Articles DO - UR - https://serbiosoc.org.rs/arch/index.php/abs/article/view/4322 SP - 517-524 AB - <p><strong>Paper description: </strong></p><ul><li>The purification and physico-chemical characterization of <em>Penicillium duclauxii</em>, <em>P. proteolyticum</em> and <em>P. griseoroseum</em> lectins has been reported.</li><li>This is the first report of the antimicrobial and antioxidant potential of lectins from <em>Penicillium</em> sp.</li><li>The lectins exhibited a moderate antioxidant potential and strong antibacterial action.</li><li>The current study will help in understanding the implications of <em>Penicillium </em>lectins in the biomedical field.</li></ul><p><strong>Abstract: </strong>Lectins are a diverse group of proteins of non-immune origin that interact specifically with glycans. Owing to their specificity, they can mediate various cellular and molecular recognition processes. To explore information on biological activities of lectins from <em>Penicillium duclauxii</em>, <em>P. proteolyticum</em> and <em>P. griseoroseum,</em> they were investigated for their antioxidant and antimicrobial activities. <em>Penicillium</em> sp. lectins exhibited moderate antioxidant activity. <em>P. duclauxii</em>, <em>P. proteolyticum</em> and <em>P. griseoroseum</em> lectins inhibited DPPH with an IC<sub>50</sub> value of 71.42, 75.04 and 82.11 µg/mL, respectively. <em>P. duclauxii</em>, <em>P. proteolyticum</em> and <em>P. griseoroseum</em> lectins inhibited the hydrogen peroxide radical with IC<sub>50</sub> values of 198.57, 209.76 and 215.31 µg/mL, respectively. <em>P. duclauxii</em> and <em>P. proteolyticum</em> lectins exhibited potent antibacterial activity against Gram-negative bacteria. <em>P. griseoroseum</em> lectin inhibited only Gram-positive bacteria. <em>Penicillium</em> sp. lectins did not exhibit antifungal activity. The biological potential of<em> Penicillium</em> sp. lectins will help to understand their biomedical applications. This is the first report on the antioxidant and antimicrobial activities of purified lectins from <em>Penicillium</em> sp.</p><p><a href="https://doi.org/10.2298/ABS190529035S">https://doi.org/10.2298/ABS190529035S</a></p><div><p><strong>Received:</strong> May 29, 2019; <strong>Revised:</strong> May 31, 2019<strong>; Accepted:</strong> June 3, 2019; <strong>Published online:</strong> June 5, 2019</p><p><strong>How to cite this article:</strong> Singh RS, Walia AK. Antioxidant and antimicrobial activities of <em>Penicillium</em> sp. Lectins. Arch Biol Sci. 2019;71(3):514-24.</p></div> ER -