CARDIOPROTECTIVE EFFECT OF CYCLOALLIIN IN ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION IN ALBINO RATS: A MECHANISTIC STUDY
Abstract
Necrosis of the myocardium due to imbalance between coronary blood supply and oxygen demand of the myocardial tissue promotes the evolution of acute myocardial infarction (MI). Onions are considered a rich source of medicinal compounds, of which cycloalliin (CYC), a sulfur containing imino compound with a cyclic structure, has been been extensively reported to exhibit various pharmacological activities. The present study aimed to elucidate the protective effect of cycloalliin in isoproternol (ISO)-induced myocardial infarction in male albino Wistar rats. Results of our investigation showed that treatment with CYC (10 mg/kg) significantly elevated both (+) and (−) left ventricular delta pressure/delta time (LVdP/dt) and decreased left ventricular end diastolic pressure LVEDP compared to the isoproterenol-treated group. The level of TBARS was significantly increased in the ISO-treated group. This was accompanied by diminished myocardial creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) activities when compared with the control group (p<0.001). In CYC-treated groups, glutathione (GSH) activity was improved significantly (p<0.05) in comparison to the ISO-treated group. Treatment with CYC showed no sign of alteration in myocardial fibers.
Keywords: cardioprotective effect; cycloalliin; isoproterenol-induced myocardial infarction; antioxidants; hemodynamic functions
Received: January 14, 2016; Revised: February 28, 2016; Accepted: March 1, 2016; Published online: August 1, 2016
How to cite this article: Peng D, Liu Q. Cardioprotective effect of cycloalliin in isoproterenol-induced myocardial infarction in albino rats: A mechanistic study. Arch Biol Sci. 2016;68(4):789-93.
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Tselios K, Sheane BJ, Gladman DD, Urowitz MB. Optimal Monitoring For Coronary Heart Disease Risk in Patients with Systemic Lupus Erythematosus: A Systematic Review. J Rheumatol. 2016;43:54-65.
Finegold JA, Asaria P, Francis DP. Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol. 2013;168:934-45.
Ibrahim ESH. Myocardial tagging by cardiovascular magnetic resonance: evolution of techniques--pulse sequences, analysis algorithms, and applications. J Cardiovasc Magn Reson. 2011;13:36.
Upaganlawar A, Gandhi H, Balaraman R. Isoproterenol induced myocardial infarction: Protective role of natural products. J Pharmacol Toxicol. 2011;6:1-17.
MacGregor DA, Prielipp RC, Butterworth JF, James RL, Royster RL. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996;109:194-200.
Rahman K. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2007;2:219-36.
Sanderson TH, Reynolds CA, Kumar R, Przyklenk K, Hüttemann M. Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation. Mol Neurobiol. 2013;47:9-23.
Kanchiswamy CN, Malnoy M, Maffei ME. Chemical diversity of microbial volatiles and their potential for plant growth and productivity. Front Plant Sci. 2015;6:151.
Cragg MG, Newman DJ. Natural products: A continuing source of novel drug leads. Biochim Biophys Acta. 2013;1830:3670-95.
Bachschmid MM, Schildknecht S, Matsui R, Zee R, Haeussler D, Cohen RA, Pimental D, Loo Bv. Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann Med. 2013;45:17-36.
Augusti KT, Jose R, Sajitha GR, Augustine P. A rethinking on the benefits and drawbacks of common antioxidants and a proposal to look for the antioxidants in allium products as ideal agents: a review. Indian J Clin Biochem. 2012;27:6-20.
Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351-8.
Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta. 1979;82:67-78.
Cabaud PG, Wroblewski F. Colorimetric measurement of lactic dehydrogenase activity of body fluids. Am J Clin Pathol. 1958;30:234-6.
Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47:469-74.
Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121-6.
Benavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW. Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci USA 2007;104:17977-82.
Rodrigo R, Libuy M, Feliú F, Hasson D. Molecular basis of cardioprotective effect of antioxidant vitamins in myocardial infarction. Biomed Res Int. 2013;2013:437613.
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