Glycoxidated ferritin induces the release of microparticles positive for Toll-like receptors derived from peripheral blood CD14+ cells

Authors

  • Luis Fernando López Soto Universidad de Sonora
  • Jose Manuel Galván Moroyoqui Universidad de Sonora
  • Juan Manuel Martínez Soto Programa de Doctorado en Ciencias de la Salud
  • Martín Almada Balderrama Programa de Maestría en Ciencias de la Salud
  • Ashley Patricia Rosales Ruíz Departamento de Ciencias Químico-Biológicas
  • Gerardo Álvarez Hernández Universidad de Sonora
  • Alma Yolanda Camacho Villa Universidad Durango Santander
  • Enrique Bolado Martínez Departamento de Ciencias Químico-Biológicas
  • Jesús Adriana Soto Guzmán Universidad de Sonora
  • Maria Del Carmen Candia Plata Universidad de Sonora

Keywords:

microparticles, Toll-like receptor (TLR), ferritin, glycation, inflammation

Abstract

Both increased serum ferritin levels and Toll-like receptor (TLR) activation show independent association with the inflammatory processes. During inflammation, cell activation and apoptosis are accompanied by the release of membrane-derived microparticles (MPs), which are considered to be mediators of intercellular communication as they induce specific responses in target cells. The aim of this study was to determine whether glycated and glycoxidated ferritin induce in vitro release TLR microparticles from CD14+ peripheral blood mononuclear cells. Peripheral blood mononuclear cells were stimulated with glycated, glycoxidated and native ferritin. The release of microparticles from CD14+ cells, the presence of TLR2+ and TLR4+ on the microparticles surface and the presence of interleukins-6 and -8 (IL-6 and IL-8) inside the microparticles after stimulation were determined by flow cytometry. The role of nuclear factor κB (NF-κB) was evaluated by pretreatment of the cells with the Bay 11-7085 inhibitor. Glycated and glycoxidated ferritin induced the release of microparticles from CD14+ cells, the majority of which expressed TLR2+ and TLR4+ on their surface and contained IL-6 and IL-8. These effects were dependent on NF-κB activation. Our findings show that glycated and glycoxidated ferritin might be involved in the release of microparticles and stimulation of inflammatory responses.

https://doi.org/10.2298/ABS160614106L

Received: June 14, 2016; Revised: August 20, 2016; Accepted: August 22, 2016; Published online: October 31, 2016

How to cite: López-Soto LF, Galván-Moroyoqui JM, Martínez-Soto JM, Almada-Balderrama M, Rosales-Ruiz AP, Álvarez-Hernández G, Camacho Villa AY, Bolado Martínez E, Soto-Guzmán JA, Candia-Plata MDC. Glycoxidated ferritin induces the release of microparticles positive for toll-like receptors derived from peripheral blood CD14+ cells. Arch Biol Sci. 2017;69(3):383-90.

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Author Biographies

Luis Fernando López Soto, Universidad de Sonora

Departamento de Medicina y Ciencias de la Salud. Universidad de Sonora, Hermosillo Sonora, México

Jose Manuel Galván Moroyoqui, Universidad de Sonora

Departamento de Medicina y Ciencias de la Salud. Universidad de Sonora, Hermosillo Sonora, México

Juan Manuel Martínez Soto, Programa de Doctorado en Ciencias de la Salud

Universidad de Sonora, Hermosillo Sonora, México

Martín Almada Balderrama, Programa de Maestría en Ciencias de la Salud

Universidad de Sonora, Hermosillo Sonora, México

Ashley Patricia Rosales Ruíz, Departamento de Ciencias Químico-Biológicas

Universidad de Sonora, Hermosillo Sonora, México

Gerardo Álvarez Hernández, Universidad de Sonora

Departamento de Medicina y Ciencias de la Salud. Universidad de Sonora, Hermosillo Sonora, México

Alma Yolanda Camacho Villa, Universidad Durango Santander

Departamento de Medicina, Universidad Durango Santander, Campus Hermosillo, Sonora, México.

Enrique Bolado Martínez, Departamento de Ciencias Químico-Biológicas

Departamento de Ciencias Químico-Biológicas. Universidad de Sonora, Hermosillo Sonora, México

Jesús Adriana Soto Guzmán, Universidad de Sonora

Departamento de Medicina y Ciencias de la Salud. Universidad de Sonora, Hermosillo Sonora, México

Maria Del Carmen Candia Plata, Universidad de Sonora

Departamento de Medicina y Ciencias de la Salud. Universidad de Sonora, Hermosillo Sonora, México

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Published

2017-08-11

How to Cite

1.
López Soto LF, Galván Moroyoqui JM, Martínez Soto JM, Almada Balderrama M, Rosales Ruíz AP, Álvarez Hernández G, Camacho Villa AY, Bolado Martínez E, Soto Guzmán JA, Candia Plata MDC. Glycoxidated ferritin induces the release of microparticles positive for Toll-like receptors derived from peripheral blood CD14+ cells. Arch Biol Sci [Internet]. 2017Aug.11 [cited 2024Mar.28];69(3):383-90. Available from: https://serbiosoc.org.rs/arch/index.php/abs/article/view/634

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