Potential anticancer activity of curcumin analogs containing sulfone on human cancer cells

Authors

  • Qiuyan Zhang 1. Allan H. Conney Laboratory for Cancer Research, Guangdong University of Technology, Guangzhou 510006, P.R. China 2. Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
  • Dongli Li 1. Allan H. Conney Laboratory for Cancer Research, Guangdong University of Technology, Guangzhou 510006, P.R. China 2. Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
  • Yue Liu Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854
  • Hui Wang Allan H. Conney Laboratory for Cancer Research, Guangdong University of Technology, Guangzhou 510006
  • Changyuan Zhang Allan H. Conney Laboratory for Cancer Research, Guangdong University of Technology, Guangzhou 510006
  • Huarong Huang Allan H. Conney Laboratory for Cancer Research, Guangdong University of Technology, Guangzhou 510006
  • Yan He Allan H. Conney Laboratory for Cancer Research, Guangdong University of Technology, Guangzhou 510006
  • Xuan Chen Allan H. Conney Laboratory for Cancer Research, Guangdong University of Technology, Guangzhou 510006
  • Zhiyun Du Allan H. Conney Laboratory for Cancer Research, Guangdong University of Technology, Guangzhou 510006
  • Xi Zheng 1. Allan H. Conney Laboratory for Cancer Research, Guangdong University of Technology, Guangzhou 510006, P.R. China 2. Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA

Abstract

Three curcumin analogs (S1-S3) containing sulfone were investigated for their effects on human prostate cancer PC-3, colon cancer HT-29, lung cancer H1299 and pancreatic cancer BxPC-3 cells. The three compounds were approximately 16- to 96-fold more active than curcumin in these cell lines as determined by the MTT assay. The effects of these compounds on cell growth were further studied in prostate cancer PC-3 cells in both two dimensional (2D) and three dimensional (3D) cultures. S1-S3 strongly inhibited the growth and induced cell death in PC-3 cells, and the effects of these compounds were associated with suppression of nuclear factor kappa B (NF-κB) transcriptional activity. Moreover, treatment of PC-3 cells with all three compounds caused a decrease in the level of phosphorylated signal transducer and activator of transcription-3 (p-STAT3) (Tyr705), but not p-STAT3 (Ser727). Only S1 and S2 decreased the presence of phosphorylated Akt (p-Akt) in PC-3 cells. These curcumin analogs warrant further in vivo studies for anticancer activities in suitable animal models.

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Published

2016-06-24

How to Cite

1.
Zhang Q, Li D, Liu Y, Wang H, Zhang C, Huang H, He Y, Chen X, Du Z, Zheng X. Potential anticancer activity of curcumin analogs containing sulfone on human cancer cells. Arch Biol Sci [Internet]. 2016Jun.24 [cited 2024Nov.22];68(1):125-33. Available from: https://serbiosoc.org.rs/arch/index.php/abs/article/view/749

Issue

Vol. 68 No. 1 (2016)

Section

Articles

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Authors grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.