Identification and partial characterization of a novel circular transcript of the Tc2n gene from rat mammary gland

Authors

  • ShiQi Zhu Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu
  • YanHong Wang Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu
  • YuLong Zhao Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu
  • Jia Chen Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu
  • Chen Chen Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu
  • YaMei Jiang Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu
  • Jing Pang Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu
  • XingTang Fang Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu
  • Hong Chen Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu
  • ChunLei Zhang Institute of Cellular and Molecular Biology, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu

Abstract

The regulatory mechanism of mammary gland development and lactation is important, as lactation not only provides healthy milk for infants, but also provides health benefits to mothers. Circular RNAs (circRNAs) have recently received much attention, but only a few have been functionally characterized. In the present study, the structure and expression profile of a rat Tc2n-derived circular RNA (cTc2n) was investigated by several protocols. The cTc2n comprised exons 10 and 11 of the Tc2n gene and had no poly(A) structure. The expression of cTc2n was significantly higher in the mammary gland of rat than in other tissues, including the heart, liver, spleen, lung, kidney, uterus and ovary. The abundance of cTc2n was the highest on day 1, and significantly declined on day 7, slightly increasing on day 21 postpartum. This finding indicates that cTc2n might play an important role in lactation.

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Published

2016-06-24

How to Cite

1.
Zhu S, Wang Y, Zhao Y, Chen J, Chen C, Jiang Y, Pang J, Fang X, Chen H, Zhang C. Identification and partial characterization of a novel circular transcript of the Tc2n gene from rat mammary gland. Arch Biol Sci [Internet]. 2016Jun.24 [cited 2024Dec.22];68(2):257-62. Available from: https://serbiosoc.org.rs/arch/index.php/abs/article/view/764

Issue

Vol. 68 No. 2 (2016)

Section

Articles

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Authors grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.