Assessment of antioxidant and antiinflammatory activities and acute toxicity of the aqueous extract from a mixture of leaves and flowers of Anabasis articulata (Forssk.) Moq.
DOI:
https://doi.org/10.2298/ABS240122011MKeywords:
Anabasis articulata (Forssk.) Moq., polyphenols, antioxidants, acute toxicity, anti-inflammatory activityAbstract
Paper description:
- Anabasis articulata (Forssk) Moq. was used in traditional medicine to treat fever, headaches, diabetes, and skin disorders including eczema and lice.
- Quantification of secondary metabolites, examination of antioxidant activity, and acute toxicity of the aqueous extract from mixtures of articulata flowers and leaves, and the in vitro and in vivo anti-inflammatory activity of the aqueous extract was examined.
- The extract exhibited in vitro antioxidant activity and showed in vitro and in vivo anti-inflammatory activities in different models.
- This plant has potential beneficial effects for treating diseases associated with inflammation.
Abstract: Colometric assays were used to quantify the secondary metabolites obtained by a decoction of the extract of Anabasis articulata (DEAA) flowers and leaves. Antioxidant activity was examined using several methods: total antioxidant capacity, the 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging assay, and the β-carotene bleaching assay. Single oral doses of 2000 and 5000 mg/kg body weight were administered to albino mice to assess acute toxicity. In vitro antiinflammatory activity was determined using the egg albumin denaturation test, and the in vivo inflammatory effect was assessed utilizing carrageenan, croton oil, and xylene-induced edema tests. Results showed that DEAA contained high amounts of polyphenols, flavonoids, and tannins and exhibited antioxidant activity in all tested assays. DEAA inhibited protein denaturation and did not cause any mortality or adverse effects. Oral administration of 200 mg/kg DEAA significantly reduced the edema induced by carrageenan, croton oil, and xylene. This study highlights the use of Anabasis articulata (Forssk.) Moq. in traditional herbal medicine. It possesses antioxidant activity and can be considered safe for oral consumption; it also has potential beneficial effects in treating diseases associated with inflammation and pain.
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Copyright (c) 2024 Yasmina Makhlouf, Amel Bouaziz, Nabil Benazi , Saliha Djidel, Assia Bentahar, Nihed Barghout, Seddik Khennouf, Saliha Dahamna
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