ULTRATRACE ELEMENT CONTENTS IN RAT TISSUES: COMPARATIVE ANALYSIS OF SERUM AND HAIR AS INDICATIVE MATRICES OF THE TOTAL BODY BURDEN

Authors

  • Anatoly V. Skalny 1. Russian Society of Trace Elements in Medicine, ANO “Centre for Biotic Medicine”, Moscow; 2. Laboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Yaroslavl; 3. All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow
  • Alexey A. Tinkov 1. Laboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Yaroslavl; 2. Department of Biochemistry, Orenburg State Medical University, Orenburg; 3. Institute of Bioelementology (Russian Satellite Centre of Trace Element – Institute for UNESCO), Orenburg State University, Orenburg
  • Andrey A. Skalny 1. Russian Society of Trace Elements in Medicine, ANO “Centre for Biotic Medicine”, Moscow; 2. Institute of Bioelementology (Russian Satellite Centre of Trace Element – Institute for UNESCO), Orenburg State University, Orenburg
  • Yulia S. Medvedeva Laboratory of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow
  • Irina B. Alchinova Laboratory of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow
  • Olga P. Ajsuvakova Department of Chemistry, Orenburg State Pedagogical University, Orenburg
  • Mikhail Yu. Karganov Laboratory of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow
  • Alexandr A. Nikonorov 1. Department of Biochemistry, Orenburg State Medical University, Orenburg; 2. Institute of Bioelementology (Russian Satellite Centre of Trace Element – Institute for UNESCO), Orenburg State University, Orenburg

Abstract

The aim of this study was to investigate the distribution of ultratrace elements in rat tissues and to perform a comparative analysis of hair and serum as potential bioindicators of the total ultratrace element content. Thirty-six male Wistar rats were fed a standard chow containing 0.006±0.000, 0.001±0.000, 0.017±0.002, 0.382±0.031, 0.168±0.014, 3.211±0.134, 0.095±0.006, 0.000±0.000, 6.675±0.336, 15.327±0.564, 0.002±0.000, and 1.185±0.202 μg/g of silver (Ag), gold (Au), cesium (Cs), gallium (Ga), germanium (Ge), lanthanum (La), niobium (Nb), platinum (Pt), rubidium (Rb), titanium (Ti), thallium (Tl) and zirconium (Zr), respectively, from weaning to 3 months old. The ultratrace element content in the liver, kidney, muscle, heart, serum and hair was assessed using inductively coupled plasma mass spectrometry. The obtained data indicate that the highest concentrations of most of the studied elements (Ti, Zr, Ge, Nb, tungsten (W), La, uranium (U), Ag, Au, Pt) are in hair, whereas the lowest were observed in the serum. Statistical analysis revealed a significant association between concentrations in the hair and other tissues for Cs, Ti, Nb, Tl, La, U and Au. At the same time, serum Cs, Rb, Ti, Ge, Nb, W, Ga, Tl and La concentrations significantly correlated with the tissue content of the respective ultratrace elements. It can be concluded that hair may be used as a potential bioindicator for certain ultratrace element content in the mammalian organism.

 

Key words: ultratrace elements; inductively coupled plasma mass spectrometry; rats; hair; chow

 

Received: September 29, 2015; Revised: October 26, 2015; Accepted: October 30, 2015; Published online: June 6, 2016

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Published

2016-09-05

How to Cite

1.
Skalny AV, Tinkov AA, Skalny AA, Medvedeva YS, Alchinova IB, Ajsuvakova OP, Karganov MY, Nikonorov AA. ULTRATRACE ELEMENT CONTENTS IN RAT TISSUES: COMPARATIVE ANALYSIS OF SERUM AND HAIR AS INDICATIVE MATRICES OF THE TOTAL BODY BURDEN. Arch Biol Sci [Internet]. 2016Sep.5 [cited 2024Dec.22];68(3):623-32. Available from: https://serbiosoc.org.rs/arch/index.php/abs/article/view/981

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Vol. 68 No. 3 (2016)

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