Analgesic and antiinflammatory activities of the capilliposide derived from Lysimachia capillipes Hemsl., a traditional Chinese medicinal herb

Authors

  • Zhipan Wu College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Haote Han College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Mengting Xu College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Yuhang Shen College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Chengcheng Gao College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Huahua Yuan College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027
  • Shouxin Li 1. College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027; 2. Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang-Malaysia Joint Research Center for Traditional Medicine, Zhejiang University, Hangzhou 310027
  • Jingkui Tian 1. College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027; 2. Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang-Malaysia Joint Research Center for Traditional Medicine, Zhejiang University, Hangzhou 310027
  • He Ye Department of Pharmacy, Zhejiang Hospital, Hangzhou 310013

DOI:

https://doi.org/10.2298/ABS200708045W

Keywords:

capilliposide, Lysimachia capillipes Hemsl., antiinflammatory, analgesic

Abstract

Paper description:

  • The Lysimachia capillipes Hemsl capilliposide (LCc) is the main bioactive component of this Chinese medicinal plant.
  • Hot-plate, body torsion and paw swelling tests, together with changes in MDA, PGE2, TNF-α, COX-1 and COX-2 levels in paw tissues determined by ELISA served to estimate the analgesic and anti-inflammatory effects of LCc in female IRC mice.
  • The presented results describe analgesic and anti-inflammatory effects of LCc and lay the foundations for further investigations of its bioactivity.

Abstract: Pain and inflammation are associated with the pathophysiology of different clinical conditions. The Lysimachia capillipes Hemsl. capilliposide (LCc) is the main bioactive component of this Chinese medicinal herb, which is widely used as a remedy for the treatment of colds and arthritis. This study investigated the analgesic and antiinflammatory activities of LCc in an animal model. LCc had no significant influence on the spleen, lung, liver and stomach coefficients in mice. Pharmacological studies showed that LCc at all doses (40, 60 and 90 mg/kg) increased the latency period of paw licking induced by thermal stimulation, and at the dose of 40 mg/kg it significantly suppressed abdominal writhing episodes of mice induced by intraperitoneal (i.p.) injection of acetic acid. LCc also had antiinflammatory effect on inflammation models. Doses of 60 and 90 mg/kg suppressed paw edema induced by subcutaneous (s.c.) injection of carrageenan. Mechanistic studies revealed that the antiinflammatory effect of LCc was associated with inhibition of the production of malondialdehyde (MDA), prostaglandin E2 (PGE2), tumor necrosis factor (TNF-α), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in paw tissue of carrageenan-injected mice. These results show that LCc has analgesic and antiinflammatory effects in mice.

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Published

2020-12-25

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1.
Wu Z, Han H, Xu M, Shen Y, Gao C, Yuan H, Li S, Tian J, Ye H. Analgesic and antiinflammatory activities of the capilliposide derived from Lysimachia capillipes Hemsl., a traditional Chinese medicinal herb. Arch Biol Sci [Internet]. 2020Dec.25 [cited 2024Oct.30];72(4):515-23. Available from: https://serbiosoc.org.rs/arch/index.php/abs/article/view/6037

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Vol. 72 No. 4 (2020)

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