THE EFFECTS OF EVODIAMINE ON SERUM TOTAL CHOLESTEROL AND TRIGLYCERIDE LEVELS ARE ASSOCIATED WITH THE ACTIVATION OF THE AMPK SIGNALING PATHWAY IN RATS WITH HYPERLIPEMIA

Authors

  • Hui Yu The Second Affiliated Hospital, Baotou Medical College, Baotou 014030
  • Hai Hu Department of Pathophysiology, Baotou Medical College, Baotou 014060
  • Wuzhuang Gong The First Affiliated Hospital, Baotou Medical College, Baotou 014010
  • Li Yang The First Affiliated Hospital, Baotou Medical College, Baotou 014010
  • Zhanli Wang 1. The First Affiliated Hospital, Baotou Medical College, Baotou 014010; 2. School of Public Health, Baotou Medical College, Baotou 014060
  • Cuifeng Wang The First Affiliated Hospital, Baotou Medical College, Baotou 014010

Abstract

Evodiamine, a naturally occurring indole alkaloid, has been reported to have numerous biological activities, including antitumor, antimicrobial and anti-inflammatory effects. Previous studies also suggest that evodiamine prevents obesity. In this study, we confirmed that evodiamine lowered the levels of serum total cholesterol (TC) and triglycerides (TG) in rats with hyperlipemia. Furthermore, our findings suggest that the activation of the AMP-activated protein kinase (AMPK) pathway might contribute in part to the effect of evodiamine on the serum levels of TC and TG.

 

Key words: evodiamine; AMP-activated protein kinase; total cholesterol; triglycerides

 

Received: September 4, 2015; Revised: October 14, 2015; Accepted: October 26, 2015; Published online: May 9, 2016

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Published

2016-09-05

How to Cite

1.
Yu H, Hu H, Gong W, Yang L, Wang Z, Wang C. THE EFFECTS OF EVODIAMINE ON SERUM TOTAL CHOLESTEROL AND TRIGLYCERIDE LEVELS ARE ASSOCIATED WITH THE ACTIVATION OF THE AMPK SIGNALING PATHWAY IN RATS WITH HYPERLIPEMIA. Arch Biol Sci [Internet]. 2016Sep.5 [cited 2024Nov.21];68(3):561-6. Available from: https://serbiosoc.org.rs/arch/index.php/abs/article/view/974

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Vol. 68 No. 3 (2016)

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